Evolution of Characterized Phosphorylation Sites in Budding Yeast

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Evolution of characterized phosphorylation sites in budding yeast.

Phosphorylation is one of the most studied and important regulatory mechanisms that modulate protein function in eukaryotic cells. Recently, several studies have investigated the evolution of phosphorylation sites identified by high-throughput methods. These studies have revealed varying degrees of evidence for constraint and plasticity, and therefore, there is currently no consensus as to the ...

متن کامل

Identification of SUMO conjugation sites in the budding yeast proteome

Post-translational modification by the small ubiquitin-like modifier (SUMO) is an important mechanism regulating protein function. Identification of SUMO conjugation sites on substrates is a challenging task. Here we employed a proteomic method to map SUMO acceptor lysines in budding yeast proteins. We report the identification of 257 lysine residues where SUMO is potentially attached. Amongst ...

متن کامل

Evolution of Human Phosphorylation Sites

Phosphorylation of proteins plays key roles in many intracellular signal pathways [3]. Gain or loss of phosphorylation sites of proteins during evolution may result in changes in signal transduction pathways. For example, FOXP2, a gene involved in speech and language, was reported to gain a potential target site for phosphorylation in humans after the human-chimpanzee divergence [2]. Here, we r...

متن کامل

Experimental Evolution of Mating Discrimination in Budding Yeast

Assortative mating, when individuals of similar phenotypes mate, likely plays a key role in preventing gene flow during speciation. Reinforcement occurs when two previously geographically separated (allopatric) groups meet after having evolved partial postzygotic isolation; they are selected to evolve or enhance assortative mating to prevent costly intergroup matings that produce only maladapti...

متن کامل

PhosphoGRID: a database of experimentally verified in vivo protein phosphorylation sites from the budding yeast Saccharomyces cerevisiae

Protein phosphorylation plays a central role in cellular regulation. Recent proteomics strategies for identifying phosphopeptides have been developed using the model organism Saccharomyces cerevisiae, and consequently, when combined with studies of individual gene products, the number of reported specific phosphorylation sites for this organism has expanded enormously. In order to systematicall...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Molecular Biology and Evolution

سال: 2010

ISSN: 0737-4038,1537-1719

DOI: 10.1093/molbev/msq090